Hepatitis B virus, referred to as hepatitis B virus for short, is a DNA virus. It is such a small virus that has infected more than 2 billion people worldwide and made nearly 300 million people become chronically infected with hepatitis B virus.
However, hepatitis B virus does not regularly invade people and seasons, so hepatitis B is a disease that needs to be defended all the time. Although there are other reference indicators in the current hepatitis B screening, it is far from enough to shake the position of "two halves of hepatitis B".
1、 Hepatitis B in two and a half
It can quickly and truly reflect whether the body is infected with the virus, as well as the current activity and infectivity of viral replication; Also remind all negative subjects to inject hepatitis B vaccine as soon as possible; At the same time, provide medical information on whether infected individuals need to seek medical treatment and whether comprehensive treatment is necessary to assist subsequent doctors in diagnosis and treatment.
2、 What is hepatitis B "big three yang" and "small three yang"?
1.HBsAg（+）、HBsAb（-）、HBeAg（+）、HBeAb（-）、HBcAb（+）。
Commonly known as "Big Three Yang", which means positive for 1, 3, and 5. "Big three positive" patients can be in two different states: chronic hepatitis B B virus carrier and chronic hepatitis B with e antigen positive, which often indicates that the virus replication in the body is more active.
Although chronic hepatitis B virus carriers are "big three positive", most of them have normal liver function and slight liver tissue damage; Chronic hepatitis B patients have abnormal liver function and significant liver tissue damage. Therefore, "Big Three Yang" does not necessarily mean the severity of the condition.
2.HBsAg（+）、HBsAb（-）、HBeAg（-）、HBeAb（+）、HBcAb（+）。
Commonly known as "Xiao San Yang", which means positive for 1, 4, and 5. 'Xiao San Yang' can be in two different states: inactive HBsAg carrier and HBeAg negative chronic hepatitis B. Most inactive HBsAg carriers have normal liver function, low levels of serum hepatitis B virus (HBV DNA), and mild liver tissue damage; However, patients with HBeAg negative chronic hepatitis B, although having "small three positives", have higher viral levels, abnormal liver function, severe liver tissue damage, and are more likely to develop into cirrhosis and liver cancer. Its' small three yang 'is caused by virus mutation.
Therefore, if the two halves of hepatitis B show "small three positive", it should not be taken lightly, and further evaluation and monitoring are required.
3、 Which is more serious, Big Three Yang or Small Three Yang?
There is no more serious statement of hepatitis B big three positive and small three positive. The judgment of the degree of illness should be combined with other indicators.
Da San Yang represents active virus replication in the body, but it does not necessarily mean that liver cells have been severely damaged. It also depends on the patient's other conditions. Many patients with Da San Yang have a high viral load and relatively mild liver function damage. Some patients with small triple positive may have low viral load but may have long-term inflammatory activity. In such cases, patients are more prone to neglect and have a higher probability of developing cirrhosis or even liver cancer.
Therefore, the severity of hepatitis B is not only judged by the size of the three positive, but also comprehensively evaluated.
4、 Which is more difficult to treat, Da San Yang or Xiao San Yang?
In fact, whether it is difficult to treat or not, and whether it can be cured or not, should be judged according to each person's specific situation:
First, Xiao Sanyang. If it is confirmed that it is a chronic hepatitis B patient, depending on the existing treatment methods, there is no way to cure it for the time being.
Secondly, if the condition is not very severe, through regular antiviral treatment, combined with liver protection, enzyme reduction, and anti fibrosis treatment, the vast majority of patients can control their condition very stably. However, it is still important to pay attention to regular follow-up and evaluate changes in the condition.
Thirdly, if severe hepatitis develops into cirrhosis or even liver cancer, it will greatly increase the difficulty of treatment. In this case, antiviral therapy is only one aspect, and a more standardized and systematic plan needs to be developed based on the actual situation.
5、 Which is more contagious, Da San Yang or Xiao San Yang?
The virus degree of the two is different. In patients with big three positive, hepatitis B virus replication is very active and infectious. At this time, it is necessary to simultaneously detect liver function indicators, and go to the hospital in time after finding abnormalities.
6、 Is it a good phenomenon for Big Three Yang to turn into Small Three Yang?
The change from hepatitis B big three positive to small three positive is actually the seroconversion of hepatitis B e antigen, which usually means that the level of the virus is declining, the function of the liver may slowly become normal, and the activity of hepatitis B virus may decline, which is usually a manifestation of more effective clearance.
There are also very few people who still have a relatively high level of virus after the emergence of "Little Three Positive" in hepatitis B. This is because of the mutation of hepatitis B virus region C. This part of the population is still in need of antiviral treatment, and is still in need of active treatment and treatment.
In general, the two half and half check of hepatitis B, no matter big three positive or small three positive, all suggest that it is related to hepatitis B virus infection, and it needs the assistance of specialized doctors for further screening.